I definitely recommend changing your overall combat style and build. I had one friend who built a barehanded character, you focus on those skills and get a couple key items and you can go around punching all your foes to death. I have built characters focused around stealth and archery or heavy two handed guys who just bust in anywhere and wreck, both can be fun approaches. Also, try taking different sides or approaches to quest lines. (Might be some slight spoilers past this point) For example if you joined the dark brotherhood before you can destroy them this time, pick a different side of the war, do the blades quest line if you haven't. You can try to become a thane and landowner in every town if you haven't before. I do not know if you have the DLCs (if you don't I suggest adding them they add quite a bit of new content) but if you have been a werewolf before you can try being a vampire this time. Also, certain quest lines have special things at the end if you push for them, like the thieves guild for instance can move to a new location (similar to dark brotherhood) and regain its glory if you do enough missions for them. Also, you can focus on collections, all the dragon priest masks for instance (there is something you can do with them as well if you haven't), or all the Daedric artifacts (there is usually one or two ppl have missed). Also, you can look around for articles about the most missed missions or easter eggs, there are usually a couple I haven't done when I look at those and that gives me something to do.