Have you ever found a repeating sound effect in a game to be irritating?

[Scorpion]

Have you ever encountered a sound effect in a game that loops continuously and became frustrating? How did it impact your overall experience? Did it distract you from gameplay or enhance your enjoyment in any way? What strategies, if any, did you use to cope with or ignore the annoyance?

[killamch89]

The inventory full/cannot carry more items notification sounds haunt my dreams. The worst offender was Fallout 4's 'You're carrying too much and cannot run!' alert combined with the movement penalty. The sound design actively punished you aurally and mechanically for an already frustrating gameplay limitation.