Resident Evil 2: All Major Puzzle Solutions, Safe Combinations, and Locker Codes

Like any proper Resident Evil game, the Resident Evil 2 remake is chock full of puzzles. There are, of course, the usual “find item X, use on item Y” puzzles, but that’s just the start. Many of the game’s puzzles are a bit more straightforward, requiring only a specific letter sequence or number combination. If you’d rather not track down the puzzle solutions yourself, we’re here to help.

Resident Evil 2 Puzzle Solutions

Resident Evil 2 puzzle solutions

An important thing to note is that most puzzle solutions aren’t randomized. When it comes to most sequence-based puzzles, the same solution works across multiple playthroughs without fail. This can save you a lot of time during subsequent playthroughs, especially if you’re going for the coveted S rank. Safe combinations, locker codes, if it’s a sequence-based puzzle, chances are good it has a static solution.

Below, we’ve listed all known sequence puzzle solutions for the Resident Evil 2 remake. Some puzzles you’ll still need to solve the old fashioned way, but these solutions should still help shave off time.

Safe Combinations

  • West Office – Left 9, Right 15, Left 7
  • Waiting Room – Left 6, Right 2, Left 11
  • Treatment Room – Left 2, Right 12, Left 8

Locker Codes

  • West Office Desk (Leon’s Desk) – NED, MRG
  • Third Floor Hallway – DCM
  • Control Room – SZF
  • Second Floor Locker Room – CAP

Medallion Statue Combinations

These combinations actually differ depending on whether you’re doing the Normal or Second Run scenario.

Normal

  • Unicorn – Fish, Scorpion, Vase
  • Lion – Lion, Branch, Bird
  • Maiden – Woman, Bow, Snake

Second Run

  • Unicorn – Twins, Scale, Worm
  • Lion – Crown, Flame, Bird
  • Maiden – Ram, Harp, Bird

Chess Plug Puzzle

Again, different solutions for Normal and Second Run scenarios.

Normal

Knight – King
Rook – Queen
Bishop – Pawn

Second Run

King – Knight
Bishop – Rook
Queen – Pawn

Greenhouse Unlock Codes

Another different in Normal and Second Run solutions

Normal

  • 3123 (grate), 2067 (lab)

Second Run

  • 2048 (grate), 5831 (lab)

Plant-42 Lab Mixture Puzzle

You guessed it, one last puzzle that differs from Normal to Second Run scenarios.

R = Red Button
G = Green Button
B = Blue Button

Normal

  • RGBRGBRG

Second Run

  • BRGRBRBGBRG

For more Resident Evil 2 guide content, be sure to read up on how to unlock the unbreakable combat knife.